Best Protein Powder for Female Weight Gain Without Side Effects

Best Protein Powder for Female Weight Gain Without Side Effects

As a woman looking to gain weight in a healthy way, finding the right protein powder can be a game-changer. But with so many options on the market, it’s crucial to choose one that’s effective, safe, and free from unwanted side effects.

In this comprehensive guide, I’ll walk you through the top protein powders for female weight gain, focusing on products that will help you reach your goals without compromising your health.

* This blog contains affiliate links, meaning I may earn a commission if you click through and make a purchase, at no additional cost to you. I only recommend products I trust and believe will add value to my readers.*


1. Overall Best Natural Weight Gainer: Naked Mass 

Price On Amazon: $66.49 (8 lbs, ~$0.52/oz)

Rating: ⭐ 4.3 out of 5 (4,287 reviews)

Naked Mass is a minimalist’s dream—just three clean ingredients: Naked Whey, Naked Casein, and organic tapioca maltodextrin. It’s made without artificial sweeteners, colors, or GMOs and is totally gluten, soy, and hormone-free. The ingredient list is refreshingly short, containing just three components: whey protein, casein protein, and organic maltodextrin derived from gluten-free oats.

Key Features:

  • Calories: 1,250 per serving
  • Protein: 50g
  • Carbs: 252g
  • BCAAs: 11.5g
  • Sugar: Just 5g
  • Flavor Options: Unflavored, Chocolate, Strawberry, Vanilla, and more

Why It’s Great for Women:

  • Clean, simple ingredients that are less likely to cause bloating or hormonal imbalance
  • High protein-to-calorie ratio helps build lean mass without excess fat
  • Perfect for blending into smoothies, oatmeal, or even baking recipes

2. Best Weight Gainer with Creatine: Optimum Nutrition Serious Mass

Price On Amazon: $47.44 (6 lbs, ~$0.49/oz) 

Rating: ⭐ 4.5 out of 5 (70,881 reviews)

Product Description:

Optimum Nutrition has built a strong reputation in the fitness supplement industry, and their Serious Mass product lives up to the company’s high standards. This high-calorie weight gainer is packed with over 20 vitamins, zinc for immune support, and creatine for muscle recovery. It’s ideal for women needing a powerful post-workout shake or calorie boost between meals.  

Key Features:
  • Calories: 1,250 per serving
  • Protein: 50g (blended)
  • Carbs: 250g+
  • Extras: Creatine Monohydrate, Vitamin C, Zinc
  • Flavor Options: Chocolate, Strawberry, Banana, Vanilla, Chocolate Peanut Butter
Why It’s Great for Women:
  • Rich in immune-boosting nutrients and free from caffeine
  • Great for lean muscle development and recovery
  • Easily customizable with fruits, nut butters, or oats for an extra-calorie kick

3. Best Budget Friendly Option: MuscleTech Mass Gainer

Price on Amazon: $34.99 (5.15 lbs, ~$0.42/oz)
Rating: ⭐ 4.3 out of 5 (3,910 reviews)

Product Description:

MuscleTech delivers a powerhouse formula with 60g protein and 1,500 calories, plus 13g of BCAAs and creatine. Designed for fast gains without compromising ingredient quality. The protein blend in this product is carefully crafted to provide optimal benefits. It includes whey protein concentrate, whey protein isolate, and hydrolyzed whey protein. This combination offers both fast and slow-digesting proteins, ensuring a steady supply of amino acids to your muscles throughout the day.

Key Features:
  • Calories: 1,500 (with milk)
  • Protein: 60g
  • Carbs: 305g
  • BCAAs: 13g+
  • Flavor: Chocolate Fudge Brownie, Vanilla Milkshake
Why It’s Great for Women:
  • High-quality protein blend supports recovery and muscle tone
  • Low sugar and clean carbs make it perfect for clean bulking
  • Great flavor that makes it feel like a treat, not a chore

4. Best Balanced Nutrition Option: Dymatize Super Mass Gainer 

Price on Amazon: $43.64 (8 servings, ~$0.45/oz)
Rating: ⭐ 4.4 out of 5 (12,775 reviews)

Product Description:

Dymatize Super Mass Gainer is a robust option for women aiming to increase their body weight and muscle mass. It’s formula features 52g protein, 245g carbs, 10.7g BCAAs, and 14 vitamins & minerals. It also includes creatine for improved strength. One of the standout features of Dymatize Super Mass Gainer is its inclusion of medium-chain triglycerides (MCTs) and dietary fiber. MCTs are a type of fat that’s easily digestible and can provide quick energy.

Key Features:
  • Calories: 1,280 per serving
  • Protein: 52g
  • Carbs: 245g
  • BCAAs: 10.7g
  • Flavors: Gourmet Vanilla, Chocolate, Fruity Pebbles
Why It’s Great for Women:
  • Offers sustained protein absorption (whey + casein)
  • Includes essential nutrients to support energy, immunity, and recovery
  • Tested for banned substances—great for peace of mind

5. Best For Immune + Energy Support: GNC Pro Performance Protein Powder

Price: $51.99 (7.14 lbs, ~$0.45/oz)
Rating: ⭐ 4.5 out of 5 (3,958 reviews)

Product Description:

GNC, a well-established name in the supplement industry, offers their Pro Performance Bulk 1340 Mass Gainer as a potent option for weight gain. As the name suggests, this powder provides a substantial 1,340 calories per serving, making it one of the most calorie-dense options on our list. What sets GNC’s Mass Gainer apart is its unique carbohydrate blend. It includes maltodextrin and a mix of oat, amaranth, and quinoa flours. This diverse carb source provides sustained energy release and adds nutritional value beyond simple sugars.

Key Features:
  • Calories: 1,340 per serving
  • Protein: 50g
  • Carbs: 277–279g
  • Glutamine: 10g
  • Flavors: Strawberries & Cream, Double Chocolate, Cookies & Cream
Why It’s Great for Women:
  • Contains high-value nutrients for energy and muscle recovery
  • Glutamine supports the immune system and gut health
  • A delicious way to support weight gain without feeling overly full or bloated

Which One Should You Choose?

All five of these mass gainers are excellent choices for women looking to gain weight in a healthy, side-effect-free way. Here’s a quick comparison:

ProductCaloriesProteinPriceBest For
Naked Mass1,25050g$66.49Clean ingredients & flexibility
Serious Mass1,25050g$47.44Overall value & nutrient blend
MuscleTech1,500 (w/ milk)60g$34.99Budget & flavor
Dymatize1,28052g$43.64Balanced nutrients & sustained release
GNC Bulk 13401,34050g$51.99Immune + energy support

No matter your choice, consistency is key. Pair your gainer with regular strength training, a healthy diet, and proper sleep—and you’ll be seeing strong, beautiful gains in no time. 


Key Considerations When Choosing a Protein Powder for Weight Gain

When selecting a protein powder for weight gain, there are several important factors to consider:

Calorie Content

The calorie content of a protein powder is crucial for weight gain. Look for products that provide a significant number of calories per serving, typically ranging from 500 to 1,300 calories. This high calorie content makes it easier to achieve a caloric surplus, which is essential for gaining weight.

Protein Quality and Quantity

The protein content and quality are vital for muscle growth and recovery. Opt for powders that provide at least 20-50 grams of protein per serving.

Look for products that use a blend of protein sources, such as whey, casein, and egg proteins, to confirm a finish amino acid profile.

Carbohydrate Content

Carbohydrates are essential for providing energy and supporting weight gain. Choose powders that contain a mix of simple and complex carbohydrates. This combination provides both immediate and sustained energy release.

Fat Content

While not all weight gain powders contain significant amounts of fat, some include healthy fats like MCTs. These can provide extra calories and may offer health benefits.

Digestibility

Consider powders that include digestive enzymes or are formulated for easy digestion. This can help minimize potential side effects like bloating or gastrointestinal discomfort, which can be common with high-calorie supplements.

Additional Nutrients

Many weight gain powders are fortified with vitamins and minerals. This can be beneficial for overall health, especially when increasing calorie intake.

Taste and Mixability

Choose a powder with a flavor you enjoy and that mixes well. This increases the likelihood that you’ll use it consistently, which is key for successful weight gain.

Allergens and Dietary Restrictions

If you have any allergies or dietary restrictions, make sure to choose a powder that aligns with your needs. There are options available that are gluten-free, lactose-free, or suitable for vegetarian and vegan diets.

Brand Reputation

Opt for products from reputable brands that are transparent about their ingredients and manufacturing processes. Look for third-party testing certifications for an extra layer of quality assurance.


How to Effectively Use Protein Powders for Weight Gain

To maximize the benefits of protein powders for weight gain, consider the following tips:

  1. Calculate your calorie needs: Determine how many calories you need to consume daily to gain weight at a healthy rate.

Typically, adding 300-500 calories per day to your maintenance calories is a good starting point.

  1. Incorporate the powder into your diet strategically: Use the protein powder to supplement your regular meals, not replace them.

You can add it to smoothies, oatmeal, or even use it in baking recipes.

  1. Time your intake: Consume your protein shake at times when it’s most useful, such as immediately after workouts or before bed to support overnight muscle recovery.
  2. Combine with strength training: To confirm that the weight you gain is primarily muscle mass, incorporate regular strength training exercises into your routine.
  3. Stay hydrated: Increased protein and calorie intake can be taxing on your kidneys, so make sure to drink plenty of water throughout the day.
  4. Monitor your progress: Keep track of your weight and body measurements to confirm you’re gaining weight at a healthy rate.

Adjust your intake as necessary.

  1. Be consistent: Weight gain takes time and consistency.

Use your protein powder regularly as part of a balanced diet for the best results.

  1. Listen to your body: If you experience any digestive discomfort or other side effects, consider adjusting your serving size or trying a different product.

Potential Side Effects and How to Avoid Them

While protein powders for weight gain are generally safe, some people may experience side effects. Here are some potential issues and how to mitigate them:

  1. Digestive discomfort: Start with a smaller serving size and gradually increase it.

Choose powders with digestive enzymes or probiotics.

  1. Bloating: This can be because of lactose intolerance or the high calorie content.

Opt for lactose-free options or spread your intake throughout the day.

  1. Headaches: These can be caused by dehydration or sensitivity to certain ingredients.

Stay well-hydrated and consider switching to a different product if persistent.

  1. Acne: Some people may experience increased acne because of hormonal changes from high protein intake.

Maintain good skincare habits and consider consulting a dermatologist if issues continue.

  1. Kidney strain: While generally not a concern for healthy people, those with kidney issues should consult a doctor before using high-protein supplements.
  2. Unwanted fat gain: Ensure you’re combining your increased calorie intake with regular exercise, particularly strength training, to promote muscle gain over fat accumulation.

Frequently Asked Questions

What is the best protein powder for female weight gain?

The best protein powder for female weight gain depends on person needs and preferences. However, products like Naked Mass, Optimum Nutrition Serious Mass, and MuscleTech Mass Gainer are all excellent options because of their high calorie content, quality protein sources, and balanced nutrient profiles.

How much protein do women need for weight gain?

Women aiming to gain weight should consume about 1.6 to 2.2 grams of protein per kilogram of body weight daily. This can be achieved through a combination of whole foods and protein supplements.

Can women use the same weight gain powders as men?

Yes, women can use the same weight gain powders as men. The main difference will be in the serving size and frequency of use, which should be adjusted based on person calorie needs and weight gain goals.

Are there any side effects of using protein powders for weight gain?

While generally safe, some people may experience digestive discomfort, bloating, or headaches when using protein powders. Starting with smaller servings and staying well-hydrated can help minimize these effects.

How long does it take to see results from using weight gain protein powders?

Results can vary, but with consistent use and a proper diet and exercise routine, you may start to see noticeable weight gain within 4-8 weeks. However, sustainable, healthy weight gain is a gradual process that can take several months.

Can vegetarians or vegans use these protein powders for weight gain?

While many weight gain powders contain animal-based proteins, there are vegan options available. Look for plant-based weight gainers that use proteins from sources like pea, rice, or hemp.

How often should I drink weight gain protein shakes?

The frequency depends on your calorie needs and diet. Some people may benefit from one shake per day, while others might need two or three.

It’s important to use these shakes to supplement your regular meals, not replace them.

Can protein powders for weight gain cause acne?

Some people may experience increased acne when consuming high amounts of protein or dairy. If you notice this effect, consider switching to a plant-based option or consulting with a dermatologist.

Are weight gain protein powders safe for teenagers?

Teenagers should prioritize getting nutrients from whole foods. If considering protein powders, it’s best to talk to a pediatrician or registered dietitian first to confirm it’s suitable for their person needs and stage of development.

Can I use weight gain protein powders if I’m lactose intolerant?

Many weight gain powders contain milk-based proteins, which can be problematic for people who have lactose intolerance. Look for lactose-free options or those that include digestive enzymes to help break down lactose.

Key Takeaways

  1. Choose a protein powder with a balanced macronutrient profile, including adequate protein, carbohydrates, and healthy fats.
  2. Look for products with a mix of fast and slow-digesting proteins for sustained muscle support.
  3. Consider formulas that include digestive enzymes or are designed for easy digestion to minimize potential side effects.
  4. Opt for products with added vitamins and minerals to support overall health during weight gain.
  5. Select a flavor and texture you enjoy to confirm consistent use in your diet.